Abstract: The Permian Shanxi Formation in the Daniudi Gas Field was deposited in delta plain environment. It was composed of interbedded sandstone and mudstone, and also generated several sets of coal and coal line. Due to the low-frequency strong interference of coal and coal line, reservoir prediction was very difficult. The model-based well-seismic inversion technique was introduced in this paper, by means of which the wave impedance of time and depth domains, lithology, physical property and gas-bearing parameters might be obtained. The prediction of single sand body was successfully carried out, and the trajectory design of horizontal wells was made. The predicted vertical well depth and thickness matched well with actual drilling in two wells. In the predicted horizontal segment in well DF2, it was drilled for over 733 m along gas reservoir, achieving good results.