Abstract: The sequence development of Mesozoic and Cenozoic cOntinental sedimentary basins in North Tarim Basin has characteristics as follows. Tectonic action controls the development of sedimentary sequences and sequences have obvious cyclicity,the development of sequences has bad completicity because of the effect of tectonic action and the differences of sequence characteristics between the border and the hinterland of the basin are distinct,and the effect of marine transgressive events makes the internal structure of sequences more complex. Based on the characteristics, the framework of sequence stratigraphy is established, 45 seismic and logging sequences are recognized in all, the spread and tectonic characteristics of sequences are described in detail, and the relationship of system domain development to resevoir and mantle combination is analysed.