Abstract: Nowadays, some Ordovician oil production wells are shut down because of asphaltene chokes in oil pipes and surface pipeline system, which has seriously affected production progresses. In order to solve this problem, we have conducted a comprehensive study on asphaltene deposition and finally obtained an effective method for asphaltene choke prevention in oil production wells. Through the study of crude oil components and asphaltene deposition in district X, we found that high content of saturated hydrocarbons and low colloid asphaltene ratio are the main causes leading to asphaltene deposition. According to these studies, we have developed some methods to prevent asphaltene chokes including mixing in asphalt dispersant, clearing slug away and optimizing ground processes. These methods have effectively solved the problems after experiments.